Possible Etiologic Mechanisms in Chemical Carcinogenesis
نویسندگان
چکیده
منابع مشابه
Possible etiologic mechanisms in chemical carcinogenesis.
Some highlights in the development of our knowledge about carcinogens as etiological agents for cancer are reviewed briefly. Advances during the past 20 years relating to metabolic activation with the genesis of reactive metabolites, molecular targets and their interactions with activated carcinogens, oncogenes as molecular targets and the dependence on cell proliferation, all relating to the i...
متن کاملMechanisms of Chemical Carcinogenesis
a very interesting model for both Dandhoff disease and Tay-Sachs disease in the human. The fourth section includes papers discussing inborn errors of connective and epidermal tissues in animals. Direct analogy to the human is more difficult in these particular models; however, there is one model that is somewhat similar to osteogenesis imperfecta. Brown's paper discussing inborn errors of carti...
متن کاملMechanisms of Chemical Carcinogenesis in the Kidneys
Chemical carcinogens are substances which induce malignant tumours, increase their incidence or decrease the time taken for tumour formation. Often, exposure to chemical carcinogens results in tissue specific patterns of tumorigenicity. The very same anatomical, biochemical and physiological specialisations which permit the kidney to perform its vital roles in maintaining tissue homeostasis may...
متن کاملMechanisms of Chemical Cooperative Carcinogenesis by Epidermal Langerhans Cells
Cutaneous squamous cell carcinoma (SCC) is the most prevalent invasive malignancy with metastatic potential. The epidermis is exposed to a variety of environmental DNA-damaging chemicals, principal among which are polyaromatic hydrocarbons (PAHs) ubiquitous in the environment, tobacco smoke, and broiled meats. Langerhans cells (LCs) comprise a network of dendritic cells situated adjacent to bas...
متن کاملGenotoxic and epigenetic chemical carcinogenesis: one process, different mechanisms.
Chemieals that induce cancer in an intact organism are called carcinogens. This term does not differentiale between their vaTiaus modes of action. In this reliiew, Wemer Lutz and Peter Maier make a mechanistic distinction between carcinogens that alter the genetic information and carcinogens that interfere with epigenetic processes. They considercardnogenesis tobe an ongoing, part1y unavoidable...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1987
ISSN: 0091-6765
DOI: 10.2307/3430578